Based on current information, the biggest issue facing nurses today is multifaceted, but a core component is the ongoing strain caused by:
Staffing Shortages:

This is a critical problem that predates the pandemic but has been significantly exacerbated.1
Short staffing leads to increased workloads, which in turn contributes to burnout, fatigue, and a higher risk of errors.2
This issue is compounded by factors like an aging population requiring more care, and difficulties in recruiting and retaining nurses.3

Burnout and Mental Health:

The intense pressures of the job, including long hours, emotional strain, and exposure to trauma, contribute to high rates of burnout.4
This has been further intensified by the COVID-19 pandemic.5
The mental well-being of nurses is a serious concern, and there's a growing need for greater support and resources.6

Workplace Safety:

This includes risks like exposure to infectious diseases, musculoskeletal injuries from lifting patients, and workplace violence.7
Nurses are often on the front lines, and ensuring their safety is paramount.8

In essence, the challenges are interconnected. Staffing shortages fuel burnout, which can then compromise safety. Addressing these issues requires a comprehensive approach that prioritizes the well-being and support of nurses.