That you can do, say, think and believe all of the "right" things...and still not succeed. You can study hard, get good grades, graduate from a outstanding university, work endless hours, be one of the premier personalities in your field (or fields) of endeavor and still be seen as a failure and actually BE a failure.

This is so hard for many to accept that most never do and they squander their short lives on meaningless quests that ultimately shorten those lives, destroy their relationships and leave them unhappy and unfulfilled.