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We use python + heavily-modified Django at the application layer. Tornado and (very selectively) node.js as web-servers. Memcached and membase / redis for object- and logical-caching, respectively. RabbitMQ as a message queue. Nginx, HAproxy and Varnish for static-delivery and load-balancing. Persistent data storage using MySQL. MrJob on EMR for map-reduce.

Oh, and User-12440020814824271234 would be unhappy if I didn't mention git.

(Some updates added August 2011.)

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