1. The single most important thing to do at 22 with regards to investing is to open a Roth IRA account and make the maximum yearly contribution. Investing 5k every year should lead to well over a million of tax free money at age 60. You can open a Roth IRA account and pick how you want to invest at any brokerage firm like Vanguard, Fidelity etc.
  2. If your company has a 401K matching program, take advantage of that. If not, decide if you want to do 401K and how much to put into it.
  3. Open a savings account at Emigrant, ING, AllyBank etc. and get the 1-2% interest that they provide instead of having your money sit in a traditional Bank of America account and collect negligible interest. I'd suggest putting 20-25% of your saving in cash regardless of your investment strategy.
  4. Take your remaining savings and invest it in index funds. Maybe 1 US index fund and 1 international index fund for starters. The simplest and arguably best way to invest to do so at fixed intervals (maybe once a month) into a pool of index funds. Vanguard has some pretty standard and inexpensive options here.
  5. If you find that you can't seem to get yourself to follow the stock market at least a couple times a week, stick with the periodic index fund investing approach. If you are pretty savvy about following the market, you may consider diversifying a small amount of money into some bond funds, sector funds like HealthCare, specific foreign funds like BIK (BRIC countries), FHKCX (China) etc, or a real-estate fund if you don't own any property.
  6. I'd stay away from individual stocks for the most part - everyone thinks they have a unique angle on a company but the market is often way ahead of you :) Picking the right individual stocks gives you the most bragging rights in social circles though!
  7. For your specific example in this question, looks like you are looking at about 30K/year post tax and expenses. Maybe put 7.5K in cash at a 1-2% interest place, 15K in a couple index funds, 7.5K in some more specific funds.
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